Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

17 Nov 2016

Abstract excerpt

A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal mitochondria, delivered from sperm, are eliminated from early mammalian embryos. Autophagy has been implicated in nematodes, but whether this mechanism is conserved in mammals has been disputed. Here, we show that cultured mouse fibroblasts and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27852436
DOI: 10.7554/elife.17896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1PMID 27852436Read ↗

Paternal Mitochondrial Destruction after Fertilization Is Mediated by a Common Endocytic and Autophagic Pathway in DrosophilaSemantic proximity Read ↗

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA TransmissionSemantic proximity Read ↗

Degradation of paternal mitochondria via mitophagySemantic proximity Read ↗

Regulation of Mitochondrial Genome Inheritance by Autophagy and Ubiquitin-Proteasome System: Implications for Health, Fitness, and FertilitySemantic proximity Read ↗

Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos.Semantic proximity Read ↗

Unique insights into maternal mitochondrial inheritance in miceSemantic proximity Read ↗

Mammalian Cell-Free System Recapitulates the Early Events of Post-Fertilization Sperm MitophagySemantic proximity Read ↗

Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilizationSemantic proximity Read ↗

Mitophagy and spermatogenesis: Role and mechanismsSemantic proximity Read ↗

OPA1 deficiency induces mitophagy through PINK1/Parkin pathway during bovine oocytes maturationSemantic proximity Read ↗

Autophagy and ubiquitin–proteasome system contribute to sperm mitophagy after mammalian fertilizationSemantic proximity Read ↗

The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.