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Article

Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs.

Epigenetics & chromatin - 25 May 2018

Ren Jun, Cheng Yi, Ming Zhen-Hua, Dong Xin-Yan, Zhou Yu-Zhong, Ding Guo-Lian, Pang Hai-Yan, Rahman Tanzil Ur, Akbar Rubab, Huang He-Feng, Sheng Jian-Zhong

Abstract excerpt

BACKGROUND: The existing reports about intergenerational or transgenerational effects of intrauterine hyperglycemia have included both intrauterine and postnatal metabolic exposure factors, while the impact of intrauterine hyperglycemia per se has not been assessed alone. A number of studies suggest DNA methylation reprogramming of gametes plays a crucial role in the metabolic inheritance, but it is unclear when...

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Identifiers

PMID: 29801514
DOI: 10.1186/s13072-018-0192-2
PMCID: PMC5968593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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