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Article

Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci.

PLoS computational biology - 1 Jan 2025

Mousavi Zeinab, Arvanitis Marios, Duong ThuyVy, Brody Jennifer A, Battle Alexis, Sotoodehnia Nona, Shojaie Ali, Arking Dan E, Bader Joel S

Abstract excerpt

MOTIVATION: Genome-wide association studies (GWAS) have identified genetic variants, usually single-nucleotide polymorphisms (SNPs), associated with human traits, including disease and disease risk. These variants (or causal variants in linkage disequilibrium with them) usually affect the regulation or function of a nearby gene. A GWAS locus can span many genes, however, and prioritizing which gene or genes in a...

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PMID: 39774334
DOI: 10.1371/journal.pcbi.1012725
PMCID: PMC11741684

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PMP22

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