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Article

A Unique Signature for Cancer‐Associated Fibroblasts in Melanoma Metastases

9 Feb 2025

Abstract excerpt

Cancer-associated fibroblasts (CAFs) represent a central cell population of the tumor microenvironment (TME). Recently, single-cell RNA-sequencing (scRNA-seq) analyses of primary tumors of different cancer entities yielded different classifications of CAF subsets underscoring the heterogeneity of CAFs within the TME. Here, we analyzed the transcriptional signatures of approximately 8400 CAFs and normal...

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PMID: 39924882
DOI: 10.1111/pcmr.70002

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