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Combining single-cell and bulk RNA sequencing to identify CAF-related signature for prognostic prediction and treatment response in patients with melanoma

8 Aug 2025

Abstract excerpt

Abstract Cancer-associated fibroblasts (CAFs) play complex roles in the tumor microenvironment (TME) of melanoma. However, their impact on prognosis and treatment response in melanoma remains unclear. In this study, ScRNA-seq data (GSE115978) were utilized to characterize CAF heterogeneity and identify marker genes in melanoma. Prognostic CAF genes were identified from the TCGA dataset and employed to construct a...

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PMID: 40781483
DOI: 10.1038/s41598-025-14979-w

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