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Article

HCN4 and arrhythmias: Insights into base mutations.

Mutation research. Reviews in mutation research - 1 Jan 2025

Fan Wei, Sun Xuemei, Yuan Ruoran, Hou Xiaojie, Wan Juyi, Liao Bin

Abstract excerpt

In the human sinoatrial node (SAN), HCN4 is the primary subtype among the four HCN (hyperpolarization activated cyclic nucleotide-gated) family subtypes. A tetramer of HCN subunits forms the ion channel conducting the hyperpolarization-activated "funny" current (If), which plays an important regulatory role in maintaining the pacemaker activity of the SAN. With the advancement of detection technologies over the...

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Identifiers

PMID: 39922561
DOI: 10.1016/j.mrrev.2025.108534

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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