Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of a KCNQ1 (c.1032 + 2 T > C) mutant human embryonic stem cell line via CRISPR base editing.

Stem cell research - 1 Jun 2024

Jiang Xiaodong, Fu Chong, Liu Qiying, Gao Jiaqi

Abstract excerpt

The KCNQ1 gene encodes a voltage-gated potassium channel, which plays an important role in the repolarization of myocardial action potentials. Mutations in this gene often result in type 1 long QT syndrome (LQT1). Here, we generated a KCNQ1 (c.1032 + 2 T > C) mutant human embryonic stem cell line (WAe009-A-1D) based on the transient expression adenine base editing system that converts base A to G. The WAe009-A-1D...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Line
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Editing

Share to Human Embryonic Stem Cells

Share to KCNQ1 Potassium Channel

Share to Mutation

Source

Identifiers

PMID: 38653148
DOI: 10.1016/j.scr.2024.103425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of a KCNQ1 (c.1032 + 2 T > C) mutant human embryonic stem cell line via CRISPR base editing.PMID 38653148Read ↗

Establishment of human embryonic stem cell lines carrying LQT1 mutations by CRISPR base editing.Semantic proximity Read ↗

Generation of a human embryonic stem cell line WAe009-A-79 carrying a long QT syndrome mutation in KCNQ1.Semantic proximity Read ↗

Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing.Semantic proximity Read ↗

Generation of pluripotent stem cell line (IPWi001-A) and a corresponding CRISPR/Cas9 modified isogenic rescue control (IPWi001-A-1) from a patient with arrhythmia-induced cardiomyopathy harboring a KCNQ1 truncating mutation.Semantic proximity Read ↗

Base Editing of Human Pluripotent Stem Cells for modeling Long QT syndromeSemantic proximity Read ↗

Generation of a human embryonic stem cell line (WAe009-A-43) carrying a Long QT syndrome related mutation in KCNH2 gene.Semantic proximity Read ↗

Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing.Semantic proximity Read ↗

Therapeutic base editing alleviates restrictive cardiomyopathy.Semantic proximity Read ↗

Functional correction of the untreatable CFTR 1717-1G>A mutation through mRNA- and sgRNA-optimized base editing.Semantic proximity Read ↗

Generation of a DMD loss-of-function mutant human embryonic stem cell lines by CRISPR base editing.Semantic proximity Read ↗

Derivation of an induced pluripotent stem cell line from a long QT syndrome type 1 patient with a pathogenic KCNQ1 c.1552C > T (p.Arg518Ter) variant.Semantic proximity Read ↗

The Advantages, Challenges, and Future of Human-Induced Pluripotent Stem Cell Lines in Type 2 Long QT Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.