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Article

Isolated medial temporal lobe amnesia (MTLA): Predictor of cerebral amyloidosis or marker of phenotype-specific vulnerability?

Revue neurologique - 1 Apr 2026

Pin G, Horowitz T, Guedj E, Felician O, Ceccaldi M, Koric L

Abstract excerpt

BACKGROUND: Medial temporal lobe amnestic syndrome (MTLA) is classically considered a hallmark of Alzheimer's disease (AD). However, emerging evidence suggests etiological heterogeneity, challenging the assumption that MTLA universally reflects AD pathology. OBJECTIVE: To determine the prevalence of amyloid pathology in isolated MTLA, identify phenotypic and genetic risk factors, and characterize associated...

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Identifiers

PMID: 41775642
DOI: 10.1016/j.neurol.2026.02.149

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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