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Article

A SuperLearner-based pipeline for the development of DNA methylation-derived predictors of phenotypic traits.

PLoS computational biology - 1 Feb 2025

Khodasevich Dennis, Holland Nina, van der Laan Lars, Cardenas Andres

Abstract excerpt

BACKGROUND: DNA methylation (DNAm) provides a window to characterize the impacts of environmental exposures and the biological aging process. Epigenetic clocks are often trained on DNAm using penalized regression of CpG sites, but recent evidence suggests potential benefits of training epigenetic predictors on principal components. METHODOLOGY/FINDINGS: We developed a pipeline to simultaneously train three...

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Topics

DNA Methylation
Humans
Epigenesis, Genetic
CpG Islands
Phenotype
Computational Biology
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Epigenomics

Child

Machine Learning

Principal Component Analysis

Aging

Male

Source

Open in PubMed Open full text

Identifiers

PMID: 39913632
DOI: 10.1371/journal.pcbi.1012768
PMCID: PMC11801726

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