Article
Divergent roles of SPOP and CHD1 in ACSL4 regulation reveal context-dependent vulnerabilities for targeting ferroptosis.
Nature communications - 30 Jun 2026
Chen Feiyu, Li Qidong, Gu Qianlin, Leo Javier, Liang Xin, Mehta Naayaa, Labanca Estefania, Shepherd Peter, Mahmud Iqbal, Wang Yin, Saenz Francisco R, Phillips Maya M, Shi Wei, Meng Chenling, Zhang Jie, Frigo Daniel E, Lu Yue, Gan Boyi, Zhao Di
Abstract excerpt
Genetic heterogeneity contributes to the variable therapeutic responses in cancers. Frequent SPOP mutations and recurrent CHD1 deletions define distinct molecular subtypes of prostate cancer (PCa) with differential responses to anti-androgen therapy. Ferroptosis, an iron-dependent cell death mechanism driven by lipid peroxidation, has emerged as a promising anticancer strategy. Here, we identify SPOP mutations...
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