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Article

SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer.

Cell death and differentiation - 1 Jun 2022

Shi Qing, Jin Xiaofeng, Zhang Pingzhao, Li Qian, Lv Zeheng, Ding Yan, He Huiying, Wang Yijun, He Yuanlong, Zhao Xiaying, Zhao Shi-Min, Li Yao, Gao Kun, Wang Chenji

Abstract excerpt

p62/SQSTM1 is a selective autophagy receptor that drives ubiquitinated cargos towards autophagic degradation. This receptor is also a stress-induced scaffold protein that helps cells to cope with oxidative stress through activation of the Nrf2 pathway. Functional disorders of p62 are closely associated with multiple neurodegenerative diseases and cancers. The gene encoding the E3 ubiquitin ligase...

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Identifiers

PMID: 34987184
DOI: 10.1038/s41418-021-00913-w
PMCID: PMC9177840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer.PMID 34987184Read ↗

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