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Article

Multiomic Mendelian Randomization Study Investigating the Impact of PCSK9 and HMGCR Inhibition on Type 2 Diabetes Across Five Populations.

Diabetes - 1 Jan 2025

Rosoff Daniel B, Wagner Josephin, Jung Jeesun, Pacher Pal, Christodoulides Constantinos, Davey Smith George, Ray David, Lohoff Falk W

Abstract excerpt

The prevalence of type 2 diabetes (T2D) varies among populations of different races/ethnicities. The influence of genetically proxied LDL cholesterol lowering through proprotein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) on T2D in non-European populations is not well established. A drug target Mendelian randomization approach was used to assess the effects of PCSK9 and HMGCR inhibition on...

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Share to Cholesterol, LDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hydroxymethylglutaryl CoA Reductases

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

Source

Open in PubMed Open full text

Identifiers

PMID: 39418486
DOI: 10.2337/db24-0451
PMCID: PMC11664021

Genes

PCSK9
HMGCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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