Structures and receptor binding activities of merbecovirus spike proteins reveal key signatures for human DPP4 adaptation

Abstract excerpt

Merbecoviruses from bats, pangolins, and hedgehogs pose significant zoonotic threats, with a limited understanding of receptor binding by their spike (S) proteins. Here, we report cryo-EM structures of GD-BatCoV (BtCoV-422) and SE-PangolinCoV (MjHKU4r-CoV-1) RBDs in complex with human DPP4 (hDPP4). These structures exhibit a substantial offset in their hDPP4 interaction interfaces, revealing a conserved...

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• Respiratory viral infections research
• SARS-CoV-2 and COVID-19 Research
• Virology and Viral Diseases