Article
Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.
mBio - 23 Feb 2016
Bornholdt Zachary A, Ndungo Esther, Fusco Marnie L, Bale Shridhar, Flyak Andrew I, Crowe James E, Chandran Kartik, Saphire Erica Ollmann
Abstract excerpt
UNLABELLED: The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune surveillance. Here, we present the crystal structure of proteolytically cleaved Ebola virus GP to a resolution of 3.3 Å. We use this structure in conjunction...
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