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Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins

3 May 2023

Abstract excerpt

Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses. One such PTM, ADP-ribosylation, has recently emerged as an important mediator of host antiviral immunity. Important for the host-virus conflict over this PTM is the addition of ADP-ribose by PARP proteins and removal of ADP-ribose by...

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PMID: 37242344
DOI: 10.3390/pathogens12050674

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