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Article

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.

Journal of virology - 28 Sept 2023

Kerr Catherine M, Parthasarathy Srivatsan, Schwarting Nancy, O'Connor Joseph J, Pfannenstiel Jessica J, Giri Emily, More Sunil, Orozco Robin C, Fehr Anthony R

Abstract excerpt

ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD+ to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains. Several ARTs, also known as PARPs, are stimulated by interferon indicating ADP-ribosylation is an important aspect of the innate immune response. All coronaviruses (CoVs) encode for a highly conserved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37695054
DOI: 10.1128/jvi.00885-23
PMCID: PMC10537751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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