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Article

Poly(ADP-ribose) potentiates ZAP antiviral activity.

PLoS pathogens - 1 Feb 2022

Xue Guangai, Braczyk Klaudia, Gonçalves-Carneiro Daniel, Dawidziak Daria M, Sanchez Katarzyna, Ong Heley, Wan Yueping, Zadrozny Kaneil K, Ganser-Pornillos Barbie K, Bieniasz Paul D, Pornillos Owen

Abstract excerpt

Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation. ZAP is active against both DNA and RNA viruses, including important human pathogens such as hepatitis B virus and type 1 human immunodeficiency virus (HIV-1). ZAP selectively binds CpG dinucleotides through its N-terminal RNA-binding domain, which...

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Identifiers

PMID: 35130321
DOI: 10.1371/journal.ppat.1009202
PMCID: PMC8853533

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