Article

Poly(ADP-ribose) potentiates ZAP antiviral activity

2020-12-17

Abstract excerpt

Zinc-finger antiviral protein (ZAP), also known as poly(ADP-ribose) polymerase 13 (PARP13), is an antiviral factor that selectively targets viral RNA for degradation. ZAP is active against both DNA and RNA viruses, including important human pathogens such as hepatitis B virus and type 1 human immunodeficiency virus (HIV-1). ZAP selectively binds CpG dinucleotides through its N-terminal RNA-binding domain, which co...

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Literature Corpus work: 7b059a91-5694-534c-9411-68d47d109359
DOI: 10.1101/2020.12.17.423219

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