Article
Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways.
The EMBO journal - 21 Jul 2004
Schuurmans Carol, Armant Olivier, Nieto Marta, Stenman Jan M, Britz Olivier, Klenin Natalia, Brown Craig, Langevin Lisa-Marie, Seibt Julie, Tang Hua, Cunningham James M, Dyck Richard, Walsh Christopher, Campbell Kenny, Polleux Franck, Guillemot François
Abstract excerpt
Neocortical projection neurons, which segregate into six cortical layers according to their birthdate, have diverse morphologies, axonal projections and molecular profiles, yet they share a common cortical regional identity and glutamatergic neurotransmission phenotype. Here we demonstrate that distinct genetic programs operate at different stages of corticogenesis to specify the properties shared by all...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Eye Proteins
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Mice
- Mice, Knockout
- Mice, Mutant Strains