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Article

In silico protein structural analysis of PRMT5 and RUVBL1 mutations arising in human cancers.

Cancer genetics - 1 Apr 2025

Al-Marrawi Majd, Petreaca Ruben C, Bouley Renee A

Abstract excerpt

DNA double strand breaks (DSBs) can be generated spontaneously during DNA replication and are repaired primarily by Homologous Recombination (HR). However, efficient repair requires chromatin remodeling to allow the recombination machinery access to the break. TIP60 is a complex conserved from yeast to humans that is required for histone acetylation and modulation of HR activity at DSBs. Two enzymatic activities...

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Source

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Identifiers

PMID: 39874873
DOI: 10.1016/j.cancergen.2025.01.002
PMCID: PMC12395466

Genes

PRMT5
RUVBL1
KAT5
RUVBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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