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Article

Weight trajectories in aging humanized APOE mice with translational validity to human Alzheimer's risk population: A retrospective analysis.

PloS one - 1 Jan 2025

Vitali Francesca, Wiegand Jean-Paul, Parker-Halstead Lillian, Tucker Allan, Diaz Brinton Roberta

Abstract excerpt

Translational validity of mouse models of Alzheimer's disease (AD) is variable. Because change in weight is a well-documented precursor of AD, we investigated whether diversity of human AD risk weight phenotypes was evident in a longitudinally characterized cohort of 1,196 female and male humanized APOE (hAPOE) mice, monitored up to 28 months of age which is equivalent to 81 human years. Autoregressive Hidden...

Read the complete abstract on PubMed

Topics

Animals
Alzheimer Disease
Humans
Male
Mice
Female
Apolipoproteins E

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Models, Animal

Aging

Mice, Transgenic

Retrospective Studies

Amyloid beta-Peptides

Weight Gain

Phenotype

Body-Weight Trajectory

Source

Open in PubMed Open full text

Identifiers

PMID: 39854369
DOI: 10.1371/journal.pone.0314097
PMCID: PMC11760569

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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