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Article

Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice.

Nature communications - 19 Jan 2026

Prateek G V, Chen Zhenghao, Wright Kevin, Di Francesco Andrea, Jojic Vladimir, Churchill Gary A, Raj Anil

Abstract excerpt

Dense temporal measurements of physiological health, using simple and consistent assays, are essential to characterize biological processes associated with aging and evaluate the effectiveness of interventions on these processes. We measured body weight in 960 genetically diverse female mice, every 7-10 days over the full course of their lifespan. We used a state space model to characterize the trajectories of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41549098
DOI: 10.1038/s41467-026-68392-6
PMCID: PMC12909300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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