Article
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
PLoS genetics - 24 Nov 2010
Jensen Victor L, Bialas Nathan J, Bishop-Hurley Sharon L, Molday Laurie L, Kida Katarzyna, Nguyen Phuong Anh T, Blacque Oliver E, Molday Robert S, Leroux Michel R, Riddle Donald L
Abstract excerpt
In harsh conditions, Caenorhabditis elegans arrests development to enter a non-aging, resistant diapause state called the dauer larva. Olfactory sensation modulates the TGF-β and insulin signaling pathways to control this developmental decision. Four mutant alleles of daf-25 (abnormal DAuer Formation) were isolated from screens for mutants exhibiting constitutive dauer formation and found to be defective in...
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