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Article

NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.

CNS neuroscience & therapeutics - 1 Jan 2025

Li Chunyi, Li Hui, Men Xuejiao, Wang Yuge, Kang Xinmei, Hu Mengyan, Su Xiaotao, Wang Shisi, Lu Danli, Shen Shishi, Huang Huipeng, Deng Xiaohui, Liu Yuxin, Zhang Lei, Cai Wei, Wu Aimin, Lu Zhengqi

Abstract excerpt

AIMS: The aim of this study is to investigate the role of glymphatic function of cerebral autosomal dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL), the most common monogenic small vessel disease caused by NOTCH3 mutation, and to explore potential therapeutic strategies to improve glymphatic function. METHODS: We assessed glymphatic influx and efflux function in CADASIL mouse models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39853935
DOI: 10.1111/cns.70140
PMCID: PMC11760990

Genes

AQP4
NOTCH3
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.PMID 39853935Read ↗

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Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.Semantic proximity Read ↗

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