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Article

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

Annals of neurology - 1 Dec 2015

Ghosh Mitrajit, Balbi Matilde, Hellal Farida, Dichgans Martin, Lindauer Ute, Plesnila Nikolaus

Abstract excerpt

OBJECTIVE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common inherited small-vessel disease, is associated with vascular aggregation of mutant Notch3 protein, dysfunction of cerebral vessels, and dementia. Pericytes, perivascular cells involved in microvascular function, express Notch3. Therefore, we hypothesize that these cells may play a role...

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Blood-Brain Barrier
CADASIL
Capillaries
Pericytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Notch3

Receptors, Notch

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PMID: 26312599
DOI: 10.1002/ana.24512

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Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.PMID 26312599Read ↗

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