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Article

Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL

21 Nov 2019

Abstract excerpt

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic paradigm of small vessel disease (SVD) caused by NOTCH3 mutations that stereotypically lead to the vascular accumulation of NOTCH3 around smooth muscle cells and pericytes. White matter (WM) lesions (WMLs) are the earliest and most frequent abnormalities, and can be associated with lacunar infarcts...

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PMID: 31753008
DOI: 10.1186/s40478-019-0844-x

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