Article
Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2011
Wallays Goedele, Nuyens Dieter, Silasi-Mansat Robert, Souffreau Joris, Callaerts-Vegh Zsuzsanna, Van Nuffelen An, Moons Lieve, D'Hooge Rudi, Lupu Florea, Carmeliet Peter, Collen Désiré, Dewerchin Mieke
Abstract excerpt
OBJECTIVE: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an adult-onset neurovascular disorder caused by stereotyped mutations in the NOTCH3 receptor. Elucidation of its pathobiology is still incomplete and remains a challenge, in part because the available preclinical mouse models to date do not reproduce the full spectrum of CADASIL pathology and...
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