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Article

Early white matter changes in CADASIL: evidence of segmental intramyelinic oedema in a pre-clinical mouse model.

Acta neuropathologica communications - 30 Apr 2014

Cognat Emmanuel, Cleophax Sabine, Domenga-Denier Valérie, Joutel Anne

Abstract excerpt

INTRODUCTION: Small vessel disease (SVD) of the brain is a leading cause of age- and hypertension-related cognitive decline and disability. Cerebral white matter changes are a consistent manifestation of SVD on neuroimaging, progressing silently for many years before becoming clinically evident. The pathogenesis of these changes remains poorly understood, despite their importance. In particular, their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24886907
DOI: 10.1186/2051-5960-2-49
PMCID: PMC4035092

Genes

NOTCH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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