Article
Decreasing translation error rate in Escherichia coli increases protein function.
BMC biotechnology - 11 Mar 2016
Musa Marina, Radman Miroslav, Krisko Anita
Abstract excerpt
BACKGROUND: Over-expressed native or recombinant proteins are commonly used for industrial and pharmaceutical purposes, as well as for research. Proteins of interest need to be purified in sufficient quantity, quality and specific activity to justify their commercial price and eventual medical use. Proteome quality was previously positively correlated with ribosomal fidelity, but not on a single protein level....
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