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Article

A mini-IRES sequence for stringent selection of high producers.

Journal of biosciences - 1 Jun 2013

Yan Jun, Yang Hailin, Yue Guohua, Gao Wenda

Abstract excerpt

Internal Ribosome Entry Site (IRES) sequences have been widely used to link the expression of two independent proteins on the same mRNA transcript. Genes encoding fluorescent proteins or drug-resistance enzymes are usually placed downstream of IRES, serving as expression indicators or selection markers. In biological applications where the upstream gene-of-interest is to be expressed at extremely high levels, it...

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PMID: 23660658
DOI: 10.1007/s12038-013-9323-x

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