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Article

Germline predisposition in multiple myeloma

17 Dec 2024

Abstract excerpt

in individuals of African ancestry. Variants were characterized using loss of heterozygosity (LOH), biallelic events, and gene expression analyses, revealing 31 variants in 3.25% of sporadic cases for which pathogenicity was supported by multiple lines of evidence. Our results suggest that the disruption of DNA damage repair pathways may play a role in MM susceptibility. These results will inform improved...

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PMID: 39845416
DOI: 10.1016/j.isci.2024.111620

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