Article
Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes.
Blood cancer discovery - 1 Nov 2024
Thibaud Santiago, Subaran Ryan L, Newman Scott, Lagana Alessandro, Melnekoff David T, Bodnar Saoirse, Ram Meghana, Soens Zachry, Genthe William, Brander Tehilla, Mouhieddine Tarek H, Van Oekelen Oliver, Houldsworth Jane, Cho Hearn Jay, Richard Shambavi, Richter Joshua, Rodriguez Cesar, Rossi Adriana, Sanchez Larysa, Chari Ajai, Moshier Erin, Jagannath Sundar, Parekh Samir, Onel Kenan
Abstract excerpt
First-degree relatives of patients with multiple myeloma are at increased risk for the disease, but the contribution of pathogenic germline variants (PGV) in hereditary cancer genes to multiple myeloma risk and outcomes is not well characterized. To address this, we analyzed germline exomes in two independent cohorts of 895 and 786 patients with multiple myeloma. PGVs were identified in 8.6% of the Discovery...
Topics
Join the communities discussing this publication.