Article
EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis.
Mucosal immunology - 1 Apr 2026
Verjan Garcia Noel, Cifuentes Jimmy Fernando, Reeves Micaela A, Hwang Jae Yeon, Park Juw Won, Galandiuk Susan, Matoba Nobuyuki
Abstract excerpt
EPICERTIN, a modified cholera toxin B subunit (CTB), facilitates mucosal healing in preclinical colitis models, but its anti-inflammatory mechanisms remain unclear. Here, we investigated EPICERTIN's effects on macrophages. In a dextran sulfate sodium-induced colitis mouse model, oral administration of EPICERTIN reduced neutrophil infiltration and increased CX3CR1+MHCIIlo/- (M2-like) over CX3CR1+MHCIIhi (M1-like)...
Topics
- Animals
- Mice
- Humans
- Colitis
- Cholera Toxin
- Macrophages
- Disease Models, Animal
- Intestinal Mucosa
- Wound Healing
- Apoptosis
- Dextran Sulfate