Article
Molecular mechanisms of resistance to human pathogenic bacteria in Caenorhabditis elegans by MEV-1 mediated oxidative stress.
Biochemical and biophysical research communications - 10 Apr 2015
Feng Na, Zhi Dejuan, Zhang Liyun, Tian Jing, Ren Hui, Li Chanhe, Zhu Hongmei, Li Hongyu
Abstract excerpt
Both mutation and knockdown in mev-1 gene render Caenorhabditis elegans susceptibility to Enterococcus faecalis infection. However, the mechanisms by which of MEV-1 defects pathogen resistance remain unclear. Here we show that mev-1RNAi causes a dramatic decrease in oxidative stress and antioxidant enzyme expressions, thereby leading to increased E. faecalis accumulation in nematode intestine. Mitochondrial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.