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Article

RNA Sequencing Explores Potential Mechanisms Underlying the Enhanced Aggressive Phenotype of HepG2 Cells Induced by Aged Zinc Oxide Nanoparticles.

International journal of nanomedicine - 1 Jan 2026

Xu Jin, Yu Na, Yang Jingya, Wang Siyu, Lin Tong, Wang Meimei

Abstract excerpt

Purpose: While aged zinc oxide nanoparticles (ZnO NPs) show reduced acute cytotoxicity, their chronic effects remain unclear. This study compared the long-term, low-dose impact of environmentally aged versus fresh ZnO NPs on enhanced aggressive phenotype in hepatocellular carcinoma cells. Material and Methods: HepG2 cells were chronically exposed (approximately 16 weeks) to low doses (1.5 µg/mL) of aged or fresh...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42152980
DOI: 10.2147/IJN.S604287
PMCID: PMC13180367

Genes

CTNNB1
STAT3
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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