Article
Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia.
Blood - 1 Feb 2008
Charles Edgar D, Green Rashidah M, Marukian Svetlana, Talal Andrew H, Lake-Bakaar Gerond V, Jacobson Ira M, Rice Charles M, Dustin Lynn B
Abstract excerpt
Hepatitis C virus (HCV) is associated with B-cell lymphoproliferative disorders such as mixed cryoglobulinemia (MC) and B-cell non-Hodgkin lymphoma (B-NHL). The pathogenesis of these disorders remains unclear, and it has been proposed that HCV drives the pro-liferation of B cells. Here we demonstrate that certain HCV(+)MC(+) subjects have clonal expansions of immunoglobulin M...
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