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Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population

15 Jan 2025

Abstract excerpt

BACKGROUND: Hereditary predisposition to breast and ovarian cancer syndrome (HBOC) is a pathological condition with increased cancer risk, including breast (BC), ovarian cancer (OC), and others. HBOC pathogenesis is caused mainly by germline pathogenic variants (GPV) in BRCA1 and BRCA2 genes. However, other relevant genes are related to this syndrome diagnosis, prognosis, and treatment, including TP53, PALB2,...

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PMID: 39815370
DOI: 10.1186/s13058-024-01957-9

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