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Prevalence of germline variants in consensus moderate-to-high-risk predisposition genes to hereditary breast and ovarian cancer in BRCA1/2-negative Brazilian patients.

Breast cancer research and treatment - 1 Feb 2021

Gomes Renan, Spinola Pricila da Silva, Brant Ayslan Castro, Matta Bruna Palma, Nascimento Caroline Macedo, de Aquino Paes Silvia Maria, Bonvicino Cibele Rodrigues, Dos Santos Anna Claudia Evangelista, Moreira Miguel Angelo Martins

Abstract excerpt

PURPOSE: This study aimed to identify and classify genetic variants in consensus moderate-to-high-risk predisposition genes associated with Hereditary Breast and Ovarian Cancer Syndrome (HBOC), in BRCA1/2-negative patients from Brazil. METHODS: The study comprised 126 index patients who met NCCN clinical criteria and tested negative for all coding exons and intronic flanking regions of BRCA1/2 genes. Multiplex...

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PMID: 33128190
DOI: 10.1007/s10549-020-05985-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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