Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis.

doi:10.1371/journal.pone.0247363

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Article

Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis.

PloS one - 1 Jan 2021

Sandoval Renata Lazari, Leite Ana Carolina Rathsam, Barbalho Daniel Meirelles, Assad Daniele Xavier, Barroso Romualdo, Polidorio Natalia, Dos Anjos Carlos Henrique, de Miranda Andréa Discaciati, Ferreira Ana Carolina Salles de Mendonça, Fernandes Gustavo Dos Santos, Achatz Maria Isabel

Abstract excerpt

Brazil is the largest country in South America and the most genetically heterogeneous. The aim of the present study was to determine the prevalence of germline pathogenic variants (PVs) in Brazilian patients with breast cancer (BC) who underwent genetic counseling and genetic testing at a tertiary Oncology Center. We performed a retrospective analysis of the medical records of Brazilian patients with BC referred...

Topics

BRCA1 Protein
BRCA2 Protein
Brazil
Breast Neoplasms
Checkpoint Kinase 2
Fanconi Anemia Complementation Group N Protein
Female
Genetic Counseling
Genetic Markers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Germ-Line Mutation

Humans

Premenopause

Retrospective Studies

Tertiary Care Centers

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 33606809
DOI: 10.1371/journal.pone.0247363
PMCID: PMC7895369

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