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Cost-effectiveness of targeted next-generation sequencing (tNGS) for detection of tuberculosis drug resistance in India, South Africa and Georgia: a modeling analysis

24 Dec 2024

Abstract excerpt

Background: Targeted next-generation sequencing (tNGS) is promising alternative to phenotypic drug susceptibility testing (pDST) for detecting drug-resistant tuberculosis (DRTB). This study explored the potential cost-effectiveness of tNGS for the diagnosis of DR-TB across 3 settings: India, South Africa and Georgia. Methods: To inform WHO guideline development group (GDG) on tNGS we developed a stochastic...

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PMID: 39810935
DOI: 10.1016/j.eclinm.2024.103003

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