Article
The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study.
BMC infectious diseases - 26 Oct 2015
Van't Hoog A H, Bergval I, Tukvadze N, Sengstake S, Aspindzelashvili R, Anthony R M, Cobelens F
Abstract excerpt
BACKGROUND: Molecular resistance detection (MRD) of resistance to second-line anti-tuberculous drugs provides faster results than phenotypic tests, may shorten treatment and allow earlier separation among patients with and without second-line drug resistance. METHODS: In a decision-analytical model we simulated a cohort of patients diagnosed with TB in a setting where drug resistant TB is highly prevalent and...
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