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Article

Targeted next-generation sequencing: a promising approach for Mycobacterium tuberculosis detection and drug resistance when applied in paucibacillary clinical samples.

Microbiology spectrum - 1 Jul 2025

Jin Wenting, Wang Meixia, Wang Yang, Zhu Beidi, Wang Qingqing, Zhou Chunmei, Li Pei, Hu Chaohui, Liu Jun, Pan Jue, Chen Jiachang, Hu Bijie

Abstract excerpt

Tuberculosis (TB) returns to be the leading infectious killer globally after coronavirus disease 2019. The World Health Organization (WHO) formally included targeted next-generation sequencing (tNGS) in its list of recommendations for Mycobacterium tuberculosis (MTB) and drug resistance (DR). In this study, we explored the application of various clinical sample types for TB diagnosis and DR profiles. In...

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Identifiers

PMID: 40492765
DOI: 10.1128/spectrum.03127-24
PMCID: PMC12211088

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