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Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage

1 Jan 2025

Abstract excerpt

Double-strand breaks (DSBs) can initiate mitotic catastrophe, a complex oncosuppressive phenomenon characterized by cell death during or after cell division. Here we unveil how cell cycle-regulated DSB repair guides disparate cell death outcomes through single-cell analysis of extended live imaging. Following DSB induction in S or G2, passage of unresolved homologous recombination intermediates into mitosis...

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PMID: 39805921
DOI: 10.1038/s41556-024-01557-x

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