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Article

Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells.

Journal of cell science - 15 Nov 2012

Noda Asao, Hirai Yuko, Hamasaki Kanya, Mitani Hiroshi, Nakamura Nori, Kodama Yoshiaki

Abstract excerpt

After an exposure to ionising radiation, cells can quickly repair damage to their genomes; however, a few unrepairable DNA double-strand breaks (DSBs) emerge in the nucleus in a prolonged culture and perpetuate as long as the culture continues. These DSBs may be retained forever in cells such as non-dividing ageing tissues, which are resistant to apoptosis. We show that such unrepairable DSBs, which had been...

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Identifiers

PMID: 22899723
DOI: 10.1242/jcs.101006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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