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Article

Mycobacterium tuberculosis peptide E7/HLA-DRB1 tetramers with different HLA-DR alleles bound CD4+ T cells might share identical CDR3 region.

Scientific reports - 2 Jul 2018

Gan Yichuan, Wang Cong, Fang Yimin, Yao Yanan, Tu Xiaoxin, Wang Jiao, Huang Xi, Tan Yaoju, Chen Tao, Zhang Kouxing, Shen Yanming, Zhou Lin, Liu Jianxiong, Lai Xiaomin

Abstract excerpt

Human CD4+ T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4+ T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4+ T cells by using E7/HLA-DR tetramers constructed with different HLA-DRB1 alleles and extracted the CDR3 amino-acid...

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Share to Antigens, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Complementarity Determining Regions

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

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Identifiers

PMID: 29967390
DOI: 10.1038/s41598-018-28344-7
PMCID: PMC6028479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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