Characterization of <i>Mycobacterium tuberculosis</i>–Specific Cells Using MHC Class II Tetramers Reveals Phenotypic Differences Related to HIV Infection and Tuberculosis Disease

Abstract excerpt

Abstract A major challenge for the development of an effective vaccine against tuberculosis (TB) is that the attributes of protective CD4+ T cell responses are still elusive for human TB. Infection with HIV type 1 is a major risk factor for TB, and a better understanding of HIV-induced alterations of Mycobacterium tuberculosis–specific CD4+ T cells that leads to failed host resistance may provide insight into...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV Research and Treatment
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology