Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene.

doi:10.1371/journal.ppat.1012803

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Article

Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene.

PLoS pathogens - 1 Jan 2025

Zhang Min, Mouzannar Karim, Zhang Zhensheng, Teraoka Yuji, Piotrowski Jason, Ishida Yuji, Tateno-Mukaidani Chise, Saito Takeshi, Abe-Chayama Hiromi, Chayama Kazuaki, Liang T Jake

Abstract excerpt

HBV genotype A has two major subtypes, A1 (commonly in Africa) and A2 (commonly in Europe) with only 4% nucleotide differences. Individuals infected with these two subtypes appear to have different clinical manifestations and virologic features. Whether such a difference results from the virus or host has not been established. Using HBV generated from molecule clones of subtypes A1 and A2 in cell culture (HBVcc),...

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Topics

Hepatitis B virus
Humans
Virus Replication
Viral Regulatory and Accessory Proteins
Trans-Activators

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Genotype

Mice

Polymorphism, Genetic

Phenotype

Hepatitis B

Hepatocytes

Source

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Identifiers

PMID: 39787208
DOI: 10.1371/journal.ppat.1012803
PMCID: PMC11717313

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