Protein stability: a single recorded mutation aids in predicting the effects of other mutations in the same amino acid site.

Abstract excerpt

MOTIVATION: Accurate prediction of protein stability is important for understanding the molecular underpinnings of diseases and for the design of new proteins. We introduce a novel approach for the prediction of changes in protein stability that arise from a single-site amino acid substitution; the approach uses available data on mutations occurring in the same position and in other positions. Our algorithm,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Amino Acid Substitution