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Article

Assessing computational tools for predicting protein stability changes upon missense mutations using a new dataset.

Protein science : a publication of the Protein Society - 1 Jan 2024

Zheng Feifan, Liu Yang, Yang Yan, Wen Yuhao, Li Minghui

Abstract excerpt

Insight into how mutations affect protein stability is crucial for protein engineering, understanding genetic diseases, and exploring protein evolution. Numerous computational methods have been developed to predict the impact of amino acid substitutions on protein stability. Nevertheless, comparing these methods poses challenges due to variations in their training data. Moreover, it is observed that they tend to...

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Identifiers

PMID: 38084013
DOI: 10.1002/pro.4861
PMCID: PMC10751734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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