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Repetitive injury induces phenotypes associated with Alzheimer's disease by reactivating HSV-1 in a human brain tissue model.

Science signaling - 7 Jan 2025

Cairns Dana M, Smiley Brooke M, Smiley Jordan A, Khorsandian Yasaman, Kelly Marilyn, Itzhaki Ruth F, Kaplan David L

Abstract excerpt

Infection with herpes simplex virus type 1 (HSV-1) in the brains of APOE4 carriers increases the risk of Alzheimer's disease (AD). We previously found that latent HSV-1 in a three-dimensional in vitro model of APOE4-heterozygous human brain tissue was reactivated in response to neuroinflammation caused by exposure to other pathogens. Because traumatic brain injury also causes neuroinflammation, we surmised that...

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Amyloid beta-Peptides
Brain Injuries
Gliosis
Herpes Simplex
Herpesvirus 1, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-1beta

Virus Activation

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PMID: 39772530
DOI: 10.1126/scisignal.ado6430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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